Laboratories

Laboratory of Anatomy Ⅰ
Associate Professor : Nobutsune Ichihara
Assistant Professor : Motoharu Oishi

Laboratory of Anatomy Ⅱ
Professor : Motoharu Sakaue
Assistant Professor : Aisa Ozawa

Laboratory of Physiology Ⅰ
(Professor : Masaru Murakami)
Assistant Professor : Kumi Matsui

Laboratory of Physiology Ⅱ
Professor : Kensuke Orito
　A．Research fields of my interests

1. Veterinary clinical pharmacology, Electropathophysiology, Pharmacokinetics, Drug-drug, Drug-food interaction in small animal medicine.
2. Quantification of limbs pain in dogs.
3. Physiology of cold sensation in humans

　B．My on-going research themes

1. Theme:　Subcutaneous concentration of drugs for dermatology disease.Electropathophysiology of vertebral diseases such as hernia.Mechanisms of old sensation using mouse model.
   Key point: We have delineated mechanisms of drugs used in small animal medicine. This research is very important to predict efficacy and adverse effects.Pain is a good index of orthopedic diseases such as joint desmopathy and bone fracture and treatment for these diseases. We generated a new equipment for quantification of pain in dogs (ACVS 2019).

Assistant Professor : Maki Inoue

Laboratory of Biochemistry
Professor : Tadashi Yamashita
　A．Research fields of my interests

1. Glycosphingolipids
2. knockout mouse, desease model

　B．My on-going research themes

1. Theme:　Gangliosides, constituting lipid rafts, regulate various biological systems by modulating intracellular signal transduction. However, precise mechanism remains unclear. Therefore, we focused on ganglioside of vascular endothelial cells and analyzed its function on tumor angiogenesis.
   Key point: We established many kinds of knockout mice and use for the research. We have revealed many diseases related with lipids. I focus on lipids and want to clarify various things in the future.

Assistant Professor : Masaki Nagane

Laboratory of Molecular Biology
Professor : Masaru Murakami

Laboratory of Veterinary Pharmacology
Assistant Professor : Tomoki Fukuyama
Assistant Professor : Noriyuki Kaji

Laboratory of Veterinary Pathology
Associate Professor : Junichi Kamiie
　A．Research fields of my interests

1. Veterinary Pathology
2. Renal disease
3. Proteomics

　B．My on-going research themes

1. Theme:　Pathogenesis of AA amyloidosis
   Key point: We are trying to clarify the pathogenesis of AA amyloidosis of human based on the comparative pathology.

Assistant Professor : Naoyuki Aihara

Laboratory of Veterinary Immunology
Associate Professor : Teruo Ikeda
Assistant Professor : Mariko Okamoto

Laboratory of Microbiology Ⅰ
Professor : Masahiro Sakaguchi
Assistant Professor : Junpei Uchiyama

Laboratory of Microbiology Ⅱ
Professor : Satoshi Taharaguchi
Assistant Professor : Kan Fujino

Laboratory of Parasitology
Professor : Hong Kean Ooi
　A．Research fields of my interests

1. Immunoparasitology in the context of host-parasite relationship
2. Epidemiology and diagnosis of helminth and protozoa infection in livestock and wildlife
3. Roles of insects and earthworms in the life cycle of parasites of livestock animals

　B．My on-going research topics

1. Theme:　The role of complement in parasitic infection
   Key point: The complement system plays a very important role in the immunity to foreign pathogen invasion. We are examining the role of the complement system in the resistance or susceptibility to various helminth infections..
2. Theme:　Dignosis of helminth and protozoa infection in animals
   Key point: Serological and moelecular biological techniques are being developed to establish the diagnosis of the parasitic infections.

Associate Professor : Kensuke Taira
　A．Research fields of my interests

1. Diagnosies of gastrointestinal parasites of livestock animals (coccidia, ascarids and Trichuris)
2. Transmission of tissue dweling nematodes (Toxocara, Angiostrongylus and Trichinella)
3. Roles of insects and earthworms in the life cycle of parasites of livestock animals

　B．My on-going research themes

1. Theme:　Transmission of tissue dweling nematodes.
   Key point: Larva migrans caused by tisseue migrating nematode larvae are of importance in veterinary and publich health. Biological mechanism of the transmission of those pathogens are investigated to prevent the diseases of animals and humans.

Laboratory of Farm Animal Internal Medicine
Professor : Ken Onda
　A．Research fields of my interests

1. Aging and health of farm animals.
2. Metabolic disorders of farm animals, especaially in dairy cows.
3. Lactation physiology in dairy cows.

　B．My on-going research themes

1. Theme:　Influence of PTH/PTHrP receptor signals for obesity and insulin resistance in dairy cows.
   Key point: Preceding targets of my PTHrP research in dairy cows are lactation and calcium metabolisim. Recently, PTH/PTHrP receptor signals affect cahexia, obesity, and insulin resistance. Therefore, I want to cralify the impact of PTH/PTH signals to periparturient metabolic disease in dairy cows, fatty liver, ketosis, and fat cow syndrome.

Associate Professor : Reiichiro Sato
　A．Research fields of my interests

1. Farm Animal Surgery (laparoscope, thoracoscope)
2. oxidant stress in cattle

　B．My on-going research themes

1. Theme:　Hepatectomy in calf
   Key point: The partical hepatectomy in calf is a challenging research in Farm animal. This operatin method is useful for not only liver abscesses, but also liver tumors such as liver tumors are highly damaged, and medical treatment is considered to be one of the treatment methods for which it is difficult to cope with them. It can be expected to lead to the stable management of producers and the supply of safe food.

Assistant Professor : Sachiko Arai
Assistant Professor : Akikazu Ishihara
Assistant Professor : Kei Kazama

Laboratory of Small Animal Internal Medicine
Associate Professor : Masaharu Hisasue
Assistant Professor : Hirotaka Igarashi

Laboratory of Small Animal Surgery
Professor : Yoko Fujii
Associate Professor : Miyoko Saito
Associate Professor : Yukihiro Fujita
Associate Professor : Takuma Aoki
　A．Research fields of my interest

1. The optimal chordal length in chordal reconstruction for mitral regurgitation in dogs.
2. Atrioventricular path graft reconstruction on arrhythmogenicity and ventricular function in dogs.
3. Vibration (cardiac murmur ) effect on interstitial cells of canine mitral valve.

　B．My on-going research themes

1. Theme: The effect of atenolol on cats with HOCM using an activity monitor.
   Key point: We have new divice for countinously checking feline activity over 1 month.
2. Theme: The "Sudden start and sudden stop" motion of mitral valve develops myxomatous changes in small-sized dogs ?
   Key point: We believe that mechanical stress is associated with mitral regurgitation in small-sized dogs.

Assosiate Professor : Satoshi Takagi
　A．Research fields of my interest

1. Development of video learning materials for veterinary clinical skills
2. Immunotherapy for cancer in dogs and cats
3. Canine obstractive upper airway syndrome

　B．My on-going research themes

1. Theme: Development of educational videos with viewpoint control.
   Key point: My research purpose is to make educational videos close to 'real' experience, For this purpose, I am trying to make videos which can change viewpoint by using 8K and virtual reality.
2. Theme: Immunostatus and immunotherapy in tumor-bearing dogs.
   Key point: To know whether immunosupuression is exist in several tumor dogs and if so, which kind of immunocheckpoint molecures affect the immunostatus is clitical for developing immunotherapy in dogs.

Assistant Professor : Eiichi Kanai

Laboratory of Clinical Diagnosis
Professor : Kazutaka Yamada
Assistant Professor : Sakurako Neo

Laboratory of Veterinary Radiology
(Professor : Kensuke Orito)
Assistant Professor : Hideki Kayanuma
Assistant Professor : Takuya Maruo

Laboratory of Animal Health Ⅰ
Professor : Kazuhiro Kawai
　A．Research fields of my interests

1. Production Medicine in dairy cattle
2. Effective prevention and treatment of bovine mastitis
3. Immunity and antioxidant activity

　B．My on-going research themes

1. Theme:　Study on effective bovine mastitis control based on mastitis control management program
   Key point: We construct a new mastitis control management program and demonstrate its effectiveness. The purpose of this study is to devise and validate an effective tool.

Assistant Professor : Yasunori Shinozuka

Laboratory of Animal Health Ⅱ
Professor : Kenji Tsukamoto
　A．Research fields of my interest

1. Avian influenza: diagnosis, surveillance and molecular pathogenesis
2. Eradication of avian leukosisi virus from parent flocks and bovine viral diarrhea virus from herds
3. Establishment of reliable genetic diagnostic tests with broad detection of diverse viruses

　B．My on-going research themes

1. Theme: Development of reliable PCR, real-time PCR, LAMP, and RPA tests for the detection of easily mutating veterinary viruses such as animal influenza, bovine viral diarrhea virus, and papillomavirus, which consist of multiple serotypes and/or genotypes
   Key point: By using originally established primer databases to design subpopulation primers, it is possible to develop reliable genetic tests to detect and subtype every virus strains. The primer database is also useful to evaluate these primers for the gene detection rates.

Assistant Professor : Hironobu Murakami

Laboratory of Infections Diseases
Professor : Makoto Nagai
　A．Research fields of my interest

1. Enteric virome of livestock and wild animals
2. Interspecies transmission and genome recombination of enteric viruses
3. Comprehensive study of pestiviruses

　B．My on-going research themes

1. Theme: Metagenomics analyses of enteric viruses detected from livestock and wild animals
   Key point: Using next generation sequencing strategy, complete genome sequences of enteric viruses from feces of animals are determined and analyzed for investigation of viral evolution and novel viruses.

Associate Professor : Fujiko Sunaga

Laboratory of Nutrition
Professor : Masaya Katsumata
　A．Research fields of my interest

1. Role of amino acid nutrition on intramuscle fat accumulation in pigs
2. Chrono-nutrition of pigs
3. Amino acid requirements of pigs

　B．My on-going research themes

1. Theme: Chrono-nutrition of pigs ― Diurnal variations of activities of digestive enzymes in small intestine of growing pigs
   Key point: What we've observed so far is that activities of digestive enzymes in small intestine have diurnal rhythms and that it might be dependent on lighting conditions and eating behaviors of pigs.
2. Theme: Amino acid requirements of pigs
   Key point: Nutrition should meet the genetics. We are interested in up-dating amino acid requirements of modern type pigs reared in Japan.

Associate Professor : Takehito Suzuki
　A．Research fields of my interest

1. Elucidation of the mechanism of functional substances derived from microorganisms and microbial fermentation products
2. Elucidation of the metabolic regulatory function of ruminal fermentation products through gene expression regulation

　B．My on-going research themes

1. Theme: Characterization of histone deacetylase inhibition in bovine ovarian granulosa cells.
   Key point: Butyrate, which is one of ruminal fermentation products, inhibits the activity of histone deacetylase and regulates gene expression through an epigenetic mechanism, while being an important energy source of ruminants. In this study, we are trying to clarify whether butyric acid affects the expression of genes involved in sex hormone production and whether its action is different from monogastric animals.
   
   

Laboratory of Veterinary Obstetrics and Gynecology
Professor : Kazuyuki Kaneko
　A．Research fields of my interests

1. The inprovement of cow's reproduction.

　B．My on-going research themes

1. Theme: The effect of the day when tromethamine dinoprost was administered after natural ovulation on the interval to ovulation, the kind of ovulated follicle, and the failure to induce ovulation in cows.
   Key point: It may make timed artificial insemination by prostaglandin treatment practical.

Assistant Professor : Michiko Noguchi

Laboratory of Veterinary Public Health Ⅰ
Professor : Yukihiko Takagi
Assistant Professor : Kazutoshi Sugita

Laboratory of Veterinary Public Health Ⅱ
(Professor : Yukihiko Takagi)
Assistant Professor : Alexandre Tomomitsu Okatani

Laboratory of Animal Science
Associate Professor : Atsushi Tsukamoto
　A．Research fields of my interest

1. Laboratory Animals
2. Clinical Pharmacology
3. Veterinary Internal Medicine

　B．My on-going research themes

1. Theme: Rodent anethesia and analgesia
   Key point: We investigate the various anesthesia and analgesia in mice and rats, which may improve the peri-operative care of these animals.
2. Theme: Drug repositioning
   Key point: We assessed novel action of approved drugs both in vivo and in vitro to clinically apply them in human and veterinary medicine

Department of Animal Science and Biotechnology

Laboratory of Animal Genetics and Breeding
(Professor : Shigeru Ooki)
Associate Professor : Norio Kansaku
Assistant Professor : Yasuko Tobari

Laboratory of Animal Reproduction
Professor : Naomi Kashiwazaki
　A．Research fields of my interests

1. Assisted reproduction technology
2. Oocyte/embryo cryopreservation
3. Rrproductionin in livestock

　B．My on-going research themes

1. Theme: Generation of genetically modufied pigs via genome-editing
   Key point: The work is a key to sustaine efficient animal-production globally.

Associate Professor : Junya Ito
　A．Research fields of my interests

1. Female reproduction
2. Reproductive Engnieering
3. Developmental Biology

　B．My on-going research themes

1. Theme:　Molecular mechanism of reproductive events (fertilization and pregnancy) in mammals using gene manipulated mice
   Key point: Human infertility is one of the social and serious problems all over the world. If morecular mechanism of fertilziation and subseuqent maintenance of pregnancy is clarifed, further improvement of the reproductive technologies are promised. Our group forcus on some genes associated to feritlization and pregnancy and try to clarify the function of these genes using transgenic and knockout mice.

Laboratory of Animal Biotechnology
Professor : Tatsuya Takizawa
　A．Research fields of my interest

1. Developmet of neuronal cells from adipose-tissure derived stem cell in vitro
2. Functional role of nitric oxide and prostanoids in the patency of the ductus arteriosus

　B．My on-going research themes

1. Theme: Functional role of nitric oxide and bisulfide in the neuronal development of adipose-tissue derived stem cells
2. Theme: Functional role of nitric oxide and prostanoids in the patency of the ductus arteriosus

Associate Professor : Kazuaki Tanaka
　A．Research fields of my interests

1. Animal Genetics
2. Population and Evolutionary Genetics
3. Laboratory Animals

　B．My on-going research themes

1. Theme: [1]　Development of genetic markers for the improvement of pig feed availability.
   [2]　Phylogeography of Ruminant Wildlife inhabiting the Japanese Archipelago.
   [3] Analysis of quantitative trait loci of seizure threshold of epilepsy using mouse model.
   Key point: [1] Joint research with corporate groups engaged in pig breeding.
   [2] Joint research with local governments on wildlife conservation.
   [3] We have established an original model mouse derived from the EL strain.
   
   

Laboratory of Animal Behavior and Management
Professor : Katsuji Uetake
　A．Research fields of my interest

1. Applied animal ethology
2. Applied animal management
3. Animal welfare

　B．My on-going research themes

1. Theme: Sustainable farming with sheep and goats
   Key point: To achieve sustainable animal production, we study sheep and goat grazing using uncultivated land in urban areas.
2. Theme: Animal welfare in animal shelter and zoo environments
   Key point: To improve the level of animal welfare, we assess it in animal shelter and zoo environments.

Assistant Professor : Chihiro Kase

Laboratory of Wildlife Ecology and Conservation
Associate Professor : Masato Minami
　A．Research fields of my interests

1. Mammal ecology

　B．My on-going research themes

1. Theme:　Life history, individual-based ecology, and behavioral ecology of sika deer (Cervus nippon)
   Key point: We have been studying 700 deer that have been individually recognized on "Kinkazan" island for 30 years. I have observed their behavior, survival, breeding and lifetime reproductive success. We are trying to contribute to the development of individual-based ecology.

Associate Professor : Hideharu Tsukada
　A．Research fields of my interest

1. Wildlife conservation and management
2. Ecology and behavior of wild carnivores
3. Disease and damage control of wildlife origine

　B．My on-going research themes

1. Theme: Enhancement of non-consumptive value of wildlife as wildlife viewing by using artificial den and feeding site
   Key point: We are planing to developg artifical den for meadium sized carnivores including badgers, red foxes and raccoon dogs to enhancement for sightability of these burrowing animals.
2. Theme: Resolving the conflict between human and wildlife
   Key point: By using newly designed electric fence we are planing to resolve wildlife damage. We are also trying to evaluate various coflicts beteween wildlife and humans, such as crop damages and infectious diseases including Echinococcosis.

Laboratory of Human-Animal Interaction and Reciprocity
Professor : Takefumi Kikusui
　A．Research fields of my interests

1. 1) Forming Functional Groups of Humans and Animals: Social Neuroendocrinology
2. 2) Human-animal Cognitive Interaction,
3. 3)Reciprocal Co-Habituation between Human and Animals

　B．My on-going research themes

1. Theme: The aim of this lab is revealing how and why animals, such as dogs, cats and horses, interact with humans and form a "symbiosis", and how this "symbiosis" can affect human beings. Based on these understandings, we propose the sustainable relationship between humans and animals in modern society.
   Key point: Animals form a "society" based on unique social orders within their species. On the other hand, Humans-Dogs and Humans-Cats form an intimate "society" with each other even though they are different species. Our research is based on how and why humans are able to live with other species by being a one whole functional group. Our future goal is to reveal how humans and animals interact with one another by understanding how dogs and cats form a functional group within their species.

Assistant Professor : Miho Nagasawa

Laboratory of Companion Animal Research
Associate Professor : Kazutaka Mogi
　A．Research fields of my interest

1. Social behaviors and undreluing neural mechanisms in mice: Affiliative behavior, Maternal behavior, Oxytocin neural system
2. Social recognition and signals in mice: Ultrasonic vocalization, Odor
3. Development of sociality, especiallly in the early life period.

　B．My on-going research themes

1. Theme: The mechanism for the development of soociality in mice
   Key point: We have especially studied mother-pup interactions and a mice model of early weaning. As neural targets, we are now focusing on oxytocn neurons or sensory neurons for massage-like stimuli. We have several transgenic mice and can use the Designer Receptors Exclusively Activated by Designer Drugs system .

Assistant Professor : Sayaka Kuze

Laboratory of Comparative Toxicology
Associate Professor : Shin Wakui
　A．Research fields of my interests

1. endocrine disturbing chemicals

　B．My on-going research themes

1. Theme: In Utero Exposure to Endocrine Disturbing Chemicals Induce Morphological and Biochemical Changes in Rats Postpuberty.
   Key point: The environmental hormone problem is a global problem.

Assistant Professor : So Maezawa

Laboratory of Food Science
Associate Professor : Wataru Mizunoya
Assistant Professor : Shiro Takeda

Laboratory of Animal Resources Economics
Professor : Shigeru Ooki
　A．Research fields of my interests

1. Food system for Livestock products

　B．My on-going research themes

1. Theme: Multinational Comparison of Food Systems of Livestock Products based on Animal Welfare
   Key point: The challenge is to make it clear that livestock products produced by breeding methods with consideration to animal welfare are more expensive.

Laboratory of Basic Education

Professor : Hiroeki Sahara
　A．Research fields of my interest

1. Oncology
2. Immunology
3. Molocular Biology

　B．My on-going research themes

1. Theme: Development of radiotherapy by using novel radiosensitizer, SQAP.
   Key point: Radiosensitizer, SQAP has possibility to improve the hypoxic environment in tumors.
2. Theme: Functional analysis of cancer related gene YTHDC2
   Key point: YTHDC2 gene, an RNA helicase, promotes cancer metastasis

Associate Professor : Yasuo Ishii
Associate Professor : Kotaro Shitori
Associate Professor : Shinji Kamisuki
　A．Research fields of my interest

1. Chemical Biology
2. Natural products chemistry
3. Medicinal Chemistry

　B．My on-going research themes

1. Theme: Isolation and structure determination of novel bioactive natural products
   Key point: We are searching for nobel compounds from culture broth of fungi that posseses antiviral, anticancer or neuroprotective activity.
2. Theme: Mechanism studies on bioactive natural products.
   Key point: We study on mechanism of action of antiviral, anticancer or neuroprotective compounds.

Assistant Professor : Yuji Hirota
Assistant Professor : Nobuo Misawa

Laboratory of Small Animal Clinics
Professor : Hiroo Madarame
　A．Research fields of my interests

1. Comparative pathology, especially comparative neuropathology.

　B．My on-going research themes

1. Theme: Diagnostic pathology of domestic and companion animals.
   Key point: I am sorry, but I can't afford to accept new research collaboration.

Professor : Nobuyuki Kanemaki
Associate Professor : Toshifumi Watanabe
Assistant Professor : Shinpei Kawarai
Assistant Professor : Tetsuro Ito
Assistant Professor : Hiroki Takahashi

Professor : Hideharu Ochiai
　A．Research fields of my interests

1. Structure and Functional analysis of amino acid transporter of canine tissues
2. Virology

　B．My on-going research themes

1. Theme:　Investigation on adenovirus of African pigmy hedgehog
   Key point: We isolated adenovirus isolated from African pigmy hedgehog. Pathology of this virus is under investigation.

(Professor : Hiroeki Sahara)
(Professor : Satoshi Taharaguchi)

Laboratory of Physiology
Professor : Kazuhiko Iwahashi
　A．Research fields of my interests

1. Neuropsychiatry

　B．My on-going research themes

1. Theme:　the relationship between genotypes of receptor neurotransmitters and neuropsychosis.
   Key point: Dopamin, serotonin, alcoholism

Associate Professor : Eiji Yoshihara

Laboratory of Biochemistry
(Professor : Katsunori Furuhata)
Associate Professor : Ohoshi Murayama
Associate Professor : Kazuyuki Sogawa
　A．Research fields of my interest

1. Search for novel diagnostic markers of pancreatic ductal adenocarcinoma
2. Search for a novel allergen in food allergy using an IgE-immunoblotting assay
3. Characteristics of fecal microbiota on alcohol-induced liver injury

　B．My on-going research themes

1. Theme: Search for novel diagnostic markers of pancreatic ductal adenocarcinoma
   Key point: Proteome analysis technology
2. Theme: Search for novel diagnostic markers for alcoholism
   Key point: Proteome analysis technology

Laboratory of Immunology
Professor : Shoichiro Miyatake
　A．Research fields of my interests

1. T cell biology
2. Inflammatory diseases and immunological check point
3. Immune regulation by transcription factors

　B．My on-going research themes

1. Theme:　Dermatitis of the GATA3 mutant mice. Mechanisms of dermatitis development and immune check point.
   The role of transcription factor ZNF131, one of GATA3 interacting molecules, in the immune system.
   Key point: I have established this dermatitis model. Interesting point is the relationship between the inflammation and immune check point.

Professor : Takashi Kuribayashi
　A．Research fields of my interests

1. Neutralizing efficacy of bovine colostral antibody against verotoxin derived from enterohemorrhagic Escherichia coli O157:H7
2. Characteristic of acute phase proteins, C-reactive protein and a2-macroglobulin, in experimental animals
3. Seroprevalence of immunoglobulin E antibodies against Japanese cedar pollen allergens Cry j 1 and Cry j 2 in dogs bred in Japan

　B．My on-going research themes

1. Theme:　Seroprevalence of IgE antibodies against Japanese cedar pollen allergens Cry j 1 and Cry j 2 in dogs, Kinetics of a2-macroglobulin in animal model of diseases, Seroprevalence of antibodies against Mycobacterium avium subsp. paratuberculosis in dogs
   Key point: a2-macroglobulin is typical acute phase protein in rats. a2-macroglobulin is possible to use as an useful inflammatory parameter in non-clinical trials of candidate drug substances. The measurement method of a2-macroglobulin has already established.There have also been few reports on the prevalence of IgE antibody against Cry j2 in dogs. The study of seroprevalence of IgE against othre allegens, cypress pollen, have already prepared.

Laboratory of Hygiene and Public Health
(Professor : Katsunori Furuhata)
Assistant Professor : Yoichi Kakuno

Laboratory of Pathology
Professor : Akinori Shimada
　A．Research fields of my interests

1. Toxicological experimental pathology: autophagy as defense mechanism
2. Inhalation toxicology by particles including silica and yellow sand (sand dust, Kosa)
3. Neuropathology of animals affected with physical, chemical and biological agents

　B．My on-going research themes

1. Theme: Inhalation toxicology by particles, including silica and yellow sand (sand dust, Kosa)
   Key point: With the use of technique of intratracheal instillation of particles including silica and yellow sand (sand dust, Kosa) to mice and rat, inhalation toxicology is carried out in my laboratory (in vivo, in vitro) with sufficient facilities, background and scientific publications.

Associate Professor : Kikumi Ogihara
　A．Research fields of my interest

1. Drug-induced autophagy : toxicology, ultrastructure, mechanism
2. L-type amino acid trans-porter1（LAT1）: canine tumor cell line, Immunohistochemistry, nude mice
3. Theileria orientalis: liver injury, macrophage, cytokine, SCID mice

　B．My on-going research themes

1. Theme: Expression of L-type amino acid trans-porter1 (LAT1) in canine tumor cells and autophagy mechanism of amino acid transporter inhibitors in the anticancer drug.
   Key point: LAT1 is associated with malignancy as a prognostic factor in canine tumors. LAT1 inhibitors can be expected to be antitumor in canine tumors.
2. Theme: Ultrastructural studies of autophagy using anticancer drugs and NSAIDs-induced liver and kidney injury model
   Key point: We analyze autophagy by immunohistochemistry, ultra-morphology and Western blot using drug-induced liver and kidney injury models, in vivo and in vitro.

Laboratory of Microbiology
Professor : Katsunori Furuhata
　A．Research fields of my interest

1. Microbial ecology
2. Microbial control

　B．My on-going research themes

1. Theme: Ecological study of Legionella spp.
   Key point: Infection source measures of legionellosis
2. Theme: Microbiological study of biofilms
   Key point: Biofilm control

Associate Professor : Naoto Ishizaki

Laboratory of Hematology
(Professor : Shoichiro Miyatake)
Associate Professor : Teruko Honda
　A．Research fields of my interests

1. Relationship between macrophage and disease

　B．My on-going research themes

1. Theme:　Mechanism of immune regulation by activated monocytes/macrophages
   Key point: Macrophages induce inflammatory changes through interaction with cells in tissues. We aim to examine the possibility of regulation of inflammatory changes by monocytes/macrophages activation that could contribute to the prevention of diseases caused by chronic inflammation.

Laboratory of Medical Technology
(Professor : Katsunori Furuhata)
Assistant Professor : Kayoko Takada

Laboratory of Food and Hygiene
Professor : Shiro Miyake
Assistant Professor : Kenji Oonaka

Laboratory of Food Safety Sciences
Professor : Yoshiko Sugita-Konishi
　A．Research fields of my interests

1. Food safety
2. Food hygiene

　B．My on-going research themes

1. Theme:　Risk assessment of Mycology and Mycotoxin
   Key point: We focus on mycotoxins contaminated in rice and a lot of new findings are published in international journals. These studies should be contributed for development of regulatory science.
2. Theme:　The methodology of new food poisoning　
   Key point: We established the genetically detection methods for New food poisoning (Kudoa genus in floounders and Sarcocystis genus in horse, deer, boar) . These methods are first reports and should be contributed for prevention of these food poisoning.
3. Theme:　Detoxification of health effect caused by Mycotoxins
   Key point: Lactococcus lactis obtained from vegetables detoxificates mycotoxin adversed effects. The study was first report in the field and should be contribute the first aid for prevention of mycotoxin effect.

Assistant Professor : Naoki Kobayashi

Laboratory of Food and Nutritional Science
Professor : Toru Moriguchi

Laboratory of Food and Physiological Sciences
Professor : Mamoru Takeda
　A．Research fields of my interests

1. Peripheral and central mechanisms of trigeminal neuropathic and inflammatory pain
2. Contribution of activation of satellite glia in sensory ganglia to pathological pain
3. Neuronal cross-talk within the trigeminal ganglia contributes to inflammatory allodynia

　B．My on-going research themes

1. Theme:　Mechanisms of nociceptive and pathological pain relief by dietary constituent
   Key point: In this study, we aim to examine the possibility for pain relief by dietary constituents, such as polyphenol compounds, carotenoids and fatty acids by using behavioral, immunohisitochemical and electrophysiological techniques. Our study contributes to potential molecular target of dietary constituent through pain pathways that could contribute to development of further functional food and analgesic agents with the free side effects. It is possible that dietary constituent could be a complementary alternative medicine, specifically a therapeutic agent.

Associate Professor : Yoshihito Shimazu

Laboratory of Food Analysis Chemistry
Professor : Yuko Kato-Yoshinaga
　A．Research fields of my interests

1. Food chemistry
2. Analytical chemisry

　B．My on-going research themes

1. Theme:　Analysis of food taste components which vary according to the methods of production, processing and preservation
   Key point: We have studied on taste components levels in bivalves, vegetables, meats and so on which change by means of the methods of production, processing and presevation, in order to investigate how to improve their tastes. We mainly analyze free amino acids and ATP-related compouds.

Assistant Professor : Chika Kitaoka-Saito

Laboratory of Public Health Nutrition
Professor : Junko Ishihara
　A．Research fields of my interest

1. Nutrition Epidemiology
2. Dietary Assessment
3. Prevention of non-communicable disease

　B．My on-going research themes

1. Theme: Analysis of diet -disease association in a large-scale prospective cohort study: Japan Public Ceneter-based prospective cohort study (JPHC study)
   Key point: JPHC study is one of the largest prospective cohort study, which started in 1990s in 11 various areas of Japan. We investigate the association between various dietary/nutritional factors and various NCDs such as cancer, cardiovascular diseases, diabetes, etc. The strength of our study is the scale of the study (n=approx. 140,000), prospective design, long and through follow-up, validated questionnaires, and multiple endpoints.
2. Theme: Risk assessment for acrylamide exposure in Japan.
   Key point: The goal of the study is to evaluate risk of cancer cause by dietary acrylamide in Japan Public Ceneter-based prospective cohort study. We developed assessment method to estimate dietary exposure level of acrylamide, and validated it using data of cohort subsample. Then we assessed the association between dietary intake of acrylamide and various cancer (breast, ovarian, endometrium, gastrointestinal, etc)
3. Theme: Assessment methodology of dietary exposure
   Key point: Validation of food frequency questionnaires. Development of new method of dietary assessment such as web-based 24-hour recall for epidemiological studies.
4. Theme: Reduction of salt intake - Intervention and observational studies
   Key point: Randomized controlled trial to investigate the effect of monitoring salt concentration of home-prepared dishes on sodium intake. An observational study for tasete preference

Assistant Professor : Junpei Yamamoto

Laboratory of Applied Food Science
（Professor : Yoshiko Sugita-Konishi）
Associate Professor : Shoko Sawano

Laboratory of Environmental Analysis
Professor : Akihide Itoh
　A．Research fields of my interest

1. Environmental dymamics analyses of trace metals in environmental water by multielement profiling analyses
2. Biogeochemical cycles of bioessential trace elements in coral reefs
3. Development of new analyical method using ICP-MS to determine trace metals in environmental and biological samples

　B．My on-going research themes

1. Theme: Potential pollution investigation for rare earth elements and other rare metals in river water and coastal seawater around urban area
   Key point: In general water quality survey, heavy metals, whose standard and guide line values were established in environmental quality standards for water pollution, are analyzed. However, the present research has the possibility to find the unkown potential environmental pollution by analyzing comprehensively trace and untratrace metals in environmental water.
2. Theme: Intake process of bioessential elements to symbiotic animals such as coral, giant cham, anemone via zooxanthellae from seawater in coral reefs
   Key point: The biogeochemical cycles of bioessential elements to support a diverce and unique ecosystem in coral reefs would be elucidated. In addition, the present research can investigate the change of nutrient intake process on coral bleaching from the view point of trace metals.

Assistant Professor : Kazuhiko Nakano

Laboratory of Water Environment
Professor : Kazuho Inaba
　A．Research fields of my interest

1. Behavior analysis of toxic substances such as synthetic chemicals and heavy metals in aquatic environment
2. Assessment and development of restoration techniques for groundwater pollution with chloroethylenes
3. Fundamental chemistry of two-phase partition systems (L-L extraction / micellar solubilization / adsorption etc) and its application to the environmental analysis and protection

　B．My on-going research themes

1. Theme: Behavior analysis of water pollution by dangerous chemicals
   Key point: Source analysis and diffusion analysis of chemical substance contamination; contamination history analysis using change of chemical substance stored in sediment core samples
2. Theme: Elution behavior of heavy metal elements by rainfall exposure from illegally dumped waste home appliances
   Key point: Validity assessment of waste management using the results obtained by Japanese Environment Ministory #13, the official measurement scheme for elution test from waste materials; long-term elution test; effect of acid rain.
3. Theme: Development of novel adsorbent to remove several pollutants such as As in groundwater, Se in flyash, or NH3 in wastewater
   Key point: Development of inexpensive and easy-to-use materials from marine waste; Evaluation of adsorptivity for harmful elements such as As and Se; development of practical application technology

Associate Professor : Yumiko Ohkouchi

Laboratory of Environmental Genetic Engineering
(Professor : Osamu Endo)
Assistant Professor : Shin Hisamatsu

Laboratory of Environmental Hygiene
Professor : Osamu Endo
Associate Professor : Masashi Sekimoto

Laboratory of Environmental Biology
Associate Professor : Yasushi Kawakami
Assistant Professor : Hirotaka Katahira

Laboratory of Cell Biology
(Professor : Osamu Endo)
Assistant Professor : Takahiro Akiyama

Seminar on Community Studies
Professor : Takehiro Okura

Laboratory of Regional Environmental Policy
(Professor : Osamu Endo)
Assistant Professor : Fumiyo Murayama

Office of International Communication

(Professor : Kazuho Inaba)
Assistant Professor : Akira Harada
Assistant Professor: Jonathan Lynch

Teacher Training Course

Professor : Toshiya Kodama
　A．Research fields of my interests

1. Environmental Education
2. Education for Sustainable Development

　B．My on-going research themes

1. Theme:　ESD curriculum development at elementary & junior high school
   Key point: The purpose of this research is to clarify what kind of impact the ESD practice at schools are on their students, teacher, and its residents.

Associate Professor : Tomonori Fukui
　A．Research fields of my interest

1. Development of school science programs in primary and secondary education stage
2. Development of teacher training programs for pre-service and in-service science teachers
3. Theoretical study on science education, environmental education, ESD, and STS

　B．My on-going research themes

1. Theme: Development of school science programs and teaching materials about issues of science and technology in modern society
   Key point: Our programs and teaching materials are very practical, because we arranged various techniques of participatory technology assessment into simple school program textbooks
2. Theme: Development of comic booklets as science teaching material focused on the characteristics of science and scientists
   Key point: Our booklet are very unique, because the comics focused on scientists and scientific characteristics directly. These booklets intend to use it in school science class as teaching materials .