麻布大学

学部・大学院ACADEMIC / GRADUATE

講師 福山 朋季 (Tomoki Fukuyama)

獣医学部 獣医学科

講師 福山 朋季 (Tomoki Fukuyama)
研究室
薬理学研究室
所属と主な研究内容
免疫毒性・アレルギー・感作性代替法の開発
担当科目
毒性学・毒性学実習

プロフィール

東京農工大学農学部獣医学科卒業後、一般財団法人残留農薬研究所にて急性毒性(経口・経皮・吸入)、皮膚感作性、刺激性、免疫毒性試験およびin vitro代替法試験等の試験責任者として14年間勤務いたしました。一般財団法人残留農薬研究所在籍中の2011年に博士号(獣医学)を岐阜大学大学院連合獣医学研究科にて取得し、2014年から2016年にかけては、米国ノースカロライナ州立大学 獣医学部 薬理学研究室に留学しました。

米国より帰国後、一般財団法人残留農薬研究所の主任研究員、室長代行を経て、平成30年10月より本学獣医学部・講師に着任しました。 研究テーマとして、①環境中化学物質により増悪される各種アレルギー疾患のメカニズム解明、②JAK阻害薬をはじめとする新規アレルギー治療薬の薬効解明、③化学物質により誘発されるアレルギーの検査法開発、に着目し研究を行っています。

研究業績

  1. Ehling S, Fukuyama T, Ko MC, Olivry T, Bäumer W. Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons. Acta Derm Venereol. 2019 in press.
  2. Tajiki-Nishino R, Watanabe Y, Fukuyama T (corresponding author). Effect of prenatal exposure to combined immunosuppressive agrochemicals in a mouse model of allergic airway inflammation. J Vet Med Sci. 2019 in press.
  3. Makino E, Fukuyama T (corresponding author), Watanabe Y, Tajiki-Nishin R, Tajima H, Ohnuma-Koyama A, Takahashi N, Ohtsuka R, Okazaki Y. Subacute oral administration of folic acid elicits anti-inflammatory response in a mouse model of allergic dermatitis. The Journal of Nutritional Biochemistry. 2019 in press.
  4. Tajima H, Tajiki-Nishino R, Watanabe Y, Fukuyama T (corresponding author). Direct activation of aryl hydrocarbon receptor by benzo(a)pyrene elicits Th2-driven pro-inflammatory responses in a mouse model of allergic dermatitis. Journal of Applied Toxicology. J Appl Toxicol. 2019 Feb 12.
  5. Watanabe Y, Tajiki-Nishino R, Tajima H, Fukuyama T (corresponding author). Role of estrogen receptors α and β in the development of allergic airway inflammation in mice: A possible involvement of interleukin 33 and eosinophils. Toxicology. 2019 Jan 1;411:93-100.
  6. Watanabe Y, Makino E, Tajiki-Nishino R, Koyama A, Tajima H, Ishimota M, Fukuyama T (corresponding author). Involvement of estrogen receptor α in pro-pruritic and pro-inflammatory responses in a mouse model of allergic dermatitis. Toxicol Appl Pharmacol. 2018 Sep 15;355:226-237.
  7. Fukuyama T, Ehling S, Wilzopolski J, Bäumer W. Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model. BMC Pharmacol Toxicol. 2018 Jul 3;19(1):37.
  8. Tajiki-Nishino R, Makino E, Watanabe Y, Tajima H, Ishimota M, Fukuyama T (corresponding author). Oral Administration of Bisphenol A Directly Exacerbates Allergic Airway Inflammation but Not Allergic Skin Inflammation in Mice. Toxicol Sci. 2018 Oct 1;165(2):314-321.
  9. Fukuyama T, Martel BC, Linder KE, Ehling S, Ganchingco JR, Bäumer W. Hypochlorous acid is antipruritic and anti-inflammatory in a mouse model of atopic dermatitis. Clin Exp Allergy. 2018 Jan;48(1):78-88.
  10. Roßbach K, Köchling H, Fukuyama T, Wilzopolski J, Kietzmann M, Bäumer W. Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis. Histamine Receptors as Drug Targets. 2017 Chapter 9.
  11. Fukuyama T, Ganchingco JR, Mishra SK, Olivry T, Rzagalinski I, Volmer DA, Bäumer W. Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor. J Allergy Clin Immunol. 2017 Jul;140(1):306-309.
  12. Nolan MW, Long CT, Marcus KL, Sarmadi S, Roback DM, Fukuyama T, Baeumer W, Lascelles BD. Nocifensive Behaviors in Mice with Radiation-Induced Oral Mucositis. Radiat Res. 2017 Mar;187(3):397-403.
  13. Fukuyama T, Ganchingco JR, and Bäumer W. Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib. Eur J Pharmacol. 2017 Jan 5;794:20-26.
  14. Cruse G, Yin Y, Fukuyama T, Desai A, Arthur GK, Bäumer W, Beaven MA, Metcalfe DD. Exon-skipping of FcεRIβ eliminates FcεRI expression in mast cells with therapeutic potential for allergy. Proc Natl Acad Sci USA. 2016 Dec 6;113(49):14115-14120.
  15. Stover K, Fukuyama T, Young AT, Daniele MA, Oberley R, Crapo JD, Bäumer W. Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis. Arch Dermatol Res. 2016 Dec;308(10):711-721.
  16. Nishino R, Fukuyama T (corresponding author), Watanabe Y, Kurosawa Y, Kosaka T, Harada T. Detection of respiratory allergies caused by environmental chemical allergen via measures of hyper-activation and degranulation of mast cells in lungs of NC/Nga mice. J Immunotoxicol. 2016 Sep;13(5):676-85.
  17. Wada K, Nishino R, Fukuyama T, Matsumoto K. Evaluation of the PIGRET assay as a short-term test using a single dose of diethylnitrosamine. Mutat Res. 2016 Nov 15;811:70-74.
  18. Nishino R, Fukuyama T (corresponding author), Watanabe Y, Kurosawa Y, Kosaka T, Harada T. Significant upregulation of cytokine secretion from T helper type 9 and 17 cells in a NC/Nga mouse model of ambient chemical exposure-induced respiratory allergy. J Pharmacol Toxicol Methods. 2016 Jul-Aug;80:35-42.
  19. Fukuyama T, Tschernig T, Qi Y, Volmer DA, Bäumer W. Aggression behaviour induced by oral administration of the Janus-kinase inhibitor tofacitinib, but not oclacitinib, under stressful conditions. Eur J Pharmacol. 2015 Oct 5;764:278-82.
  20. Fukuyama T, Ehling S, Cook E, Bäumer W. Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis. J Pharmacol Exp Ther. 2015 Sep;354(3):394-405.
  21. Wada K, Fukuyama T, Nakashima N, Matsumoto K. Assessment of the in vivo genotoxicity of cadmium chloride, chloroform, and D,L-menthol as coded test chemicals using the alkaline comet assay. Mutat Res Genet Toxicol Environ Mutagen. 2015 Jul;786-788:114-9.
  22. Shimada Y, Tomita M, Yoshida T, Fukuyama T, Katoh Y, Ohnuma-Koyama A, Takahashi N, Soma K, Kojima S, Ohtsuka R, Takeda M, Kuwahara M, Harada T. Inhibition of lipopolysaccharide-induced liver injury in rats treated with a hepatic drug-metabolizing enzyme inducer p,p'-DDT. Exp Toxicol Pathol. 2015 Mar;67(3):245-51.
  23. Nishino R, Fukuyama T (corresponding author), Watanabe Y, Kurosawa Y, Ueda H, Kosaka T. Effect of mouse strain in a model of chemical-induced respiratory allergy. Exp Anim. 2014;63(4):435-45.
  24. Fukuyama T (corresponding author), Nishino R, Kosaka T, Watanabe Y, Kurosawa Y, Ueda H, Harada T. Effects of prior oral exposure to combinations of environmental immunosuppressive agents on ovalbumin allergen-induced allergic airway inflammation in Balb/c mice. Immunopharmacol Immunotoxicol. 2014 Aug;36(4):261-70.
  25. Nishino R, Fukuyama T (corresponding author), Kosaka T, Hayashi K, Watanabe Y, Kurosawa Y, Ueda H, Harada T. Effects of short-term oral combined exposure to environmental immunotoxic chemicals in mice. J Immunotoxicol. 2014 Oct;11(4):359-66.
  26. Nishino R, Fukuyama T (corresponding author), Tajima Y, Miyashita L, Watanabe Y, Ueda H, Kosaka T. Prior oral exposure to environmental immunosuppressive chemicals Methoxychlor, Parathion, or Piperonyl Butoxide aggravates allergic airway inflammation in NC/Nga mice. Toxicology. 2013 Jul 5;309:1-8.
  27. Tomita M, Yoshida T, Fukumori J, Yamaguchi S, Kojima S, Fukuyama T, Ohnuma-Koyama A, Takahashi N, Takeuchi-Kashimoto Y, Kuwahara M, Nakashima N, Ohtsuka R, Takeda M, Kosaka T, Harada T. p,p'-DDT induces microcytic anemia in rats. J Toxicol Sci. 2013;38(5):775-82.
  28. Hayashi K, Fukuyama T, Ohnuma A, Tajima Y, Kashimoto Y, Yoshida T, Kosaka T. Immunotoxicity of the organochlorine pesticide methoxychlor in female ICR, BALB/c, and C3H/He mice. J Immunotoxicol. 2013 Apr-Jun;10(2):119-24.
  29. Fukuyama T (corresponding author), Kosaka T, Hayashi K, Miyashita L, Tajima Y, Wada K, Nishino R, Ueda H, Harada T. Role of regulatory T cells in the induction of atopic dermatitis by immunosuppressive chemicals. Toxicol Lett. 2012 Sep 18;213(3):392-401.
  30. Fukuyama T (corresponding author), Tajima Y, Hayashi K, Ueda H, Kosaka T. Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in NC/Nga mice. Toxicology. 2011 Nov 18;289(2-3):132-40.
  31. Ohnuma A, Yoshida T, Horiuchi H, Fukumori J, Tomita M, Kojima S, Takahashi N, Fukuyama T, Hayashi K, Yamaguchi S, Ohtsuka R, Kashimoto Y, Kuwahara M, Takeda M, Kosaka T, Nakashima N, Harada T. Altered pulmonary defense system in lung injury induced by didecyldimethylammonium chloride in mice. Inhal Toxicol. 2011 Jul;23(8):476-85.
  32. Fukuyama T (corresponding author), Tajima Y, Ueda H, Hayashi K, Kosaka T. Prior Exposure to Immunosuppressive Organophosphorus or Organochlorine Compounds Aggravates the TH1- and TH2-type Allergy Caused by Topical Sensitization to 2,4-Dinitrochlorobenzene and Trimellitic Anhydride. J Immunotoxicol. 2011 Jun;8(2):170-82.
  33. Fukuyama T (corresponding author), Kosaka T, Tajima Y, Hayashi K, Shutoh Y, Harada, T. Detection of thymocytes apoptosis in mice induced by organochlorine pesticides methoxychlor. Immunopharmacol Immunotoxicol 2011 Mar;33(1):193-200.
  34. Fukuyama T (corresponding author), Kosaka T, Tajima Y, Ueda H, Hayashi K, Shutoh Y, Harada T. Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens in a local lymph node assay. Toxicol Lett 2010 Dec 15;199(3):347-56.
  35. Ohnuma A, Yoshida T, Tajima H, Fukuyama T, Hayashi K, Yamaguchi S, Ohtsuka R, Sasaki J, Fukumori J, Tomita M, Kojima S, Takahashi N, Takeuchi Y, Kuwahara M, Takeda M, Kosaka T, Nakashima N, Harada T. Didecyldimethylammonium chloride induces pulmonary inflammation and fibrosis in mice. Exp Toxicol Pathol. 2010 Nov;62(6):643-51.
  36. Tajima H, Yoshida T, Ohnuma A, Fukuyama T, Hayashi K, Yamaguchi S, Ohtsuka R, Sasaki J, Tomita M, Kojima S, Takahashi N, Kashimoto Y, Kuwahara M, Takeda M, Kosaka T, Nakashima N, Harada T. Pulmonary injury and antioxidant response in mice exposed to arsenate and hexavalent chromium and their combination. Toxicology. 2010 Jan 12;267(1-3):118-24.
  37. Fukuyama T (corresponding author), Tajima Y, Ueda H, Hayashi K, Shutoh Y, Harada T, Kosaka T. Apoptosis in immunocytes induced by several types of pesticides. J Immunotoxicol 2010 Mar;7(1):39-56.
  38. Fukuyama T (corresponding author), Tajima Y, Ueda H, Hayashi K, Shutoh Y, Harada T, Kosaka T. A method for measuring mouse respiratory allergic reaction to low-dose chemical exposure to allergens: an environmental chemical of uncertain allergenicity, a typical contact allergen and a non-sensitizing irritant. Toxicol Lett 2010 May 19;195(1):35-43.
  39. Fukuyama T (corresponding author), Tajima Y, Ueda H, Hayashi K, Shutoh Y, Harada T, Kosaka T. Allergic reaction induced by dermal and/or respiratory exposure to low-dose phenoxyacetic acid, organophosphorus, and carbamate pesticides. Toxicology 2009 Jul 10;261(3):152-61.
  40. Fukuyama T (corresponding author), Ueda H, Hayashi K, Tajima Y, Shuto Y, Saito TR, Harada T, Kosaka T. Investigation of the chemical-induced selective type II (Th2) allergic response in mice: effect of the length of the sensitizing phase. J Immunotoxicol 2009 Jun;6(2):75-83.
  41. Fukuyama T (corresponding author), Ueda H, Hayashi K, Tajima Y, Shuto Y, Saito TR, Harada T, Kosaka T. Use of long term dermal sensitization followed by intratracheal challenge method to identify low-dose chemical-induced respiratory allergic responses in mice. Toxicol Lett 2008 Oct 1;181(3):163-70.
  42. Fukuyama T (corresponding author), Ueda H, Hayashi K, Tajima Y, Shuto Y, Saito TR, Harada T, Kosaka T. Detection of low-level environmental chemical allergy by a long-term sensitization method. Toxicol Lett 2008 Jul 30;180(1):1-8.
  43. Fukuyama T, Tajima Y, Ueda H, Hayashi K, Shutoh Y, Kosaka T, Harada T. Sensitizing potential of chromated copper arsenate in local lymph node assays differs with the solvent used. J Immunotoxicol 2008 Apr;5(2):99-106.
  44. Shimizu M, Tanaka R, Fukuyama T, Aoki R, Orito K, Yamane Y. Cardiac Remodeling and Angiotensin II-Forming Enzyme Activity of the Left Ventricle in Hamsters with Chronic Pressure Overload Induced by Ascending Aortic Stenosis. J Vet Med Sci 2006 Mar;68(3):271-6.

委員会活動等

  • 日本免疫毒性学会 評議員
  • 日本免疫毒性学会 AOP作成委員
  • 日本代替法評価センター 資料編纂委員会 (皮膚感作性試験) 委員
  • Journal of Immunotoxicology 編集委員
  • Annals of Pharmacology & Pharmaceutics 編集委員